Daptomycin_Anti-Bacterial_Anti-Infection_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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CAS	103060-53-3
Chinese Name	达托霉素
English Name	Daptomycin
Synonym	LY146032
Unit	Bottle
Purity	≥97%
Molecular Formula	C₇₂H₁₀₁N₁₇O₂₆
Molecular Weight	1620.67
Appearance	Light yellow to yellow solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in water/DMSO
EC	EINECS 600-389-2
MDL	MFCD08282794
InChIKey	DOAKLVKFURWEDJ-RWDRXURGSA-N
InChI	InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45+,46+,47+,48+,49+,50-,60+,61+/m1/s1
PubChem CID	16134395
SMILES	O=C(N[C@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@@H](C(N[C@H]1CC(O)=O)=O)C)=O)([H])CC(O)=O)=O)CCCN)=O)=O)[C@H](OC([C@](NC([C@](NC([C@@](NC(CNC1=O)=O)([H])CO)=O)([H])[C@H](C)CC(O)=O)=O)([H])CC(C(C=CC=C2)=C2N)=O)=O)C)=O)=O)[C@@H](NC(CCCCCCCCC)=O)CC3=CNC4=CC=CC=C34
Description	It is a cyclic lipopeptide antibiotic, which mainly has a strong bacteriostatic effect on Gram-positive cocci. It achieves antibacterial effects by destroying the function of bacterial cell membranes in many ways, including disrupting the transport of amino acids by the cell membrane, thereby hindering bacterial cell wall peptides. Biosynthesis of glycans and muramates, altering cell membrane potential.
Target Point	Bacterial
Passage	Anti-infection
Data Literature Source	[1]. Benson CA, et al. Comparative in-vitro activity of LY146032 a new peptolide, with vancomycin and eight other agents against gram-positive organisms. J Antimicrob Chemother. 1987 Aug;20(2):191-6. [2]. Miniter PM, et al. Activity of LY146032 in vitro and in experimental enterococcal pyelonephritis. Antimicrob Agents Chemother. 1987 Aug;31(8):1199-203. [3]. Allen NE, et al. Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032. Antimicrob Agents Chemother. 1987 Jul;31(7):1093-9.
Specification	20mg 10mM1mL (in DMSO) 10mM1mL in Water 50mg