CAS |
1177-87-3 |
Chinese Name |
醋酸地塞米松 |
English Name |
Dexamethasone Acetate |
Synonym |
乙酸地塞米松;醋酸氟美松 |
Unit |
Bottle |
Purity |
HPLC≥98% |
Molecular Formula |
C24H31FO6 |
Molecular Weight |
434.5 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO≥10mg/ml |
MDL |
MFCD00027407 |
EC |
EINECS 214-646-8 |
InChIKey |
AKUJBENLRBOFTD-RPRRAYFGSA-N |
InChI |
InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1 |
PubChem CID |
236702 |
SMILES |
C[C@@]1([C@@]2(O)C(COC(C)=O)=O)[C@](C[C@H]2C)([H])[C@@](CCC3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C1 |
Description |
Dexamethasone Acetate is a glucocorticoid receptor agonist with anti-inflammatory and immunosuppressive activity. |
Target Point |
Glucocorticoid Receptor (GR, or GCR) |
Passage |
Immunology & Inflammation |
Data Literature Source |
[1]. LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.
[2]. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11
[3]. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56
[4]. Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. |
Specification |
100mg 10mM*1mL (in DMSO) 500mg |