| CAS |
14534-61-3 |
| Chinese Name |
异绿原酸B |
| English Name |
3,4-Dicaffeoylquinic acid |
| Synonyms |
异绿原酸B;3，4-二咖啡酰奎宁酸;IsochlorogenicacidB; |
| Molecular Formula |
C25H24O12 |
| Molecular Weight |
516.46 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
Light yellow to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD08272439 |
| SMILES |
O=C([C@@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@H](O)C1)O |
| InChIKey |
UFCLZKMFXSILNL-PSEXTPKNSA-N |
| InChI |
InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23-,25+/m1/s1 |
| PubChem CID |
5281780 |
| Target Point |
Others |
| Passage |
Others |
| Background |
3,4-Dicaffeoylquinic acid has apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. |
| Biological Activity |
3，4-Dicaffeoylquinic acid (3，4-Di-O-caffeoylquinic acid)， naturally isolated from Laggera alata， has antioxidative， DNA protective， neuroprotective and hepatoprotective properties. 3，4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3，4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity， that is， enhancing viral clearance by increasing TRAIL[1-3]. |
| In Vitro |
3，4-Dicaffeoylquinic acid acts as a greater primary antioxidant than its methanol extract，by having higher ferric reducing activity(EC50 2.18 μg/ml)，β-carotene bleaching activity(EC50 23.85 μg/ml)and DPPH scavenging activity(EC50 68.91 μg/ml). 3，4-Dicaffeoylquinic acid exhibits a remarkable dose-dependent inhibitory effect on NCI-H23(human lung adenocarcinoma)cell lines(EC50 3.26 μg/ml)and is found to be apoptotic in nature based on a clear indication of DNA fragmentation. 3，4-Dicaffeoylquinic acid also displays a concentration-dependent α-glucosidase inhibition with EC50 241.80 μg/ml[1]. |
| Data Literature Source |
[1]. Takemura T，et al. 3，4-Dicaffeoylquinic Acid，a Major Constituent of Brazilian Propolis，Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evid Based Complement Alternat Med. 2012;2012:946867.
[2]. Liu X，et al. Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice. Basic Clin Pharmacol Toxicol. 2019;124(2):144-153.
[3]. Ooi KL，et al. Cytotoxic，apoptotic and anti-α-glucosidase activities of 3，4-di-O-caffeoyl quinic acid，an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth. J Ethnopharmacol. 2011;135(3):685-695. |
| Unit |
Bottle |
| Specification |
5mg 10mM*1mL in DMSO 10mg |
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