CAS |
512-04-9 |
Chinese Name |
薯蓣皂苷元 |
English Name |
Diosgenin |
Synonym |
Nitogenin; |
Unit |
Bottle |
Purity |
HPLC≥98% |
Molecular Formula |
C27H42O3 |
Molecular Weight |
414.63 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in ethanol≥5mg/ml,soluble in water/DMSO<1 mg/ml |
MDL |
MFCD00016887 |
EC |
EINECS 208-134-3 |
InChIKey |
WQLVFSAGQJTQCK-VKROHFNGSA-N |
InChI |
InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 |
PubChem CID |
99474 |
SMILES |
[C@@H]1(O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@]1([H])[C@H](C)[C@]4(OC[C@H](C)CC4)O[C@@]1([H])C3)CC=2 |&1:0,4,8,10,12,14,18,20,22,25,30,r| |
Description |
It is a steroid saponin that can inhibit STAT3 signaling pathway. It is also an activator of Pdia3/ERp57. |
Target Point |
STAT;Pdia3/ERp57 |
Passage |
JAK/STAT Signaling;ER Stress |
Data Literature Source |
[1]. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207.
[2]. Tohda C, et al. Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535.
[3]. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324–7331 |
Specification |
10mg 50mg |