| CAS |
512-04-9 |
| Chinese Name |
薯蓣皂苷元 |
| English Name |
Diosgenin |
| Synonyms |
薯蓣皂苷配基;Nitogenin;山药;薯蓣皂素 |
| Molecular Formula |
C27H42O3 |
| Molecular Weight |
414.63 |
| Solubility |
Soluble in Ethanol ≥5mg/mL;Soluble in Water/DMSO ＜ 1 mg/mL |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 208-134-3 |
| MDL |
MFCD00016887 |
| SMILES |
[C@@H]1(O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@]1([H])[C@H](C)[C@]4(OC[C@H](C)CC4)O[C@@]1([H])C3)CC=2 |&1:0,4,8,10,12,14,18,20,22,25,30,r| |
| InChIKey |
WQLVFSAGQJTQCK-VKROHFNGSA-N |
| InChI |
InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 |
| PubChem CID |
99474 |
| Target Point |
STAT;Pdia3/ERp57 |
| Passage |
JAK/STAT Signaling;ER Stress |
| Background |
It is a steroid saponin that can inhibit STAT3 signaling pathway. It is also an activator of Pdia3/ERp57. |
| Biological Activity |
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. |
| In Vitro |
Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner，with maximum inhibition occurring at around 100 μM[1].In MC65 cells，a cellular AD model，diosgenin exhibited weak protective abilities at 1 μM，may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[3]. |
| In Vivo |
Diosgenin-treated 5XFAD mice exhibited significantly improved performance of object recognition memory. Diosgenin treatment significantly reduced amyloid plaques and neurofibrillary tangles in the cerebral cortex and hippocampus. Degenerated axons and presynaptic terminals that were only observed in regions closely associated with amyloid plaques were significantly reduced by diosgenin treatment. The 1，25D -membrane-associated，rapid response steroid-binding protein(1，25D -MARRS)was shown to be a target of diosgenin.[2] |
| Data Literature Source |
[1]. Li F，et al. Diosgenin，a steroidal saponin，inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207.
[2]. Tohda C，et al. Diosgenin is an exogenous activator of 1，25D -MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535.
[3]. Jeremy E. Chojnacki，et al. Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry，23 (2015) 7324–7331 |
| Unit |
Bottle |
| Specification |
10mg 50mg |
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