Doxorubicin Hydrochloride_Topoisomerase_DNA Damage & DNA Repai_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	25316-40-9
Chinese Name	盐酸阿霉素
English Name	Doxorubicin Hydrochloride
Synonym	盐酸阿霉素;盐酸多柔比星;阿得里亚霉素;14-羟正定霉素;阿霉素;
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₂₇H₂₉NO₁₁·HCl
Molecular Weight	579.99
Appearance	Orange to red solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in water/DMSO
MDL	MFCD00077757
EC	EINECS 246-818-3
InChIKey	MWWSFMDVAYGXBV-RUELKSSGSA-N
InChI	InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
PubChem CID	443939
SMILES	COC1=C2C(C(C(C(O)=C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@@]4([H])C[C@H](N)[C@H](O)[C@H](C)O4)C3=C5O)=C5C2=O)=O)=CC=C1.[H]Cl
Description	It is a cytotoxic anthracycline antibiotic and is commonly used as a chemotherapy agent for cancer. It inhibits DNA replication by inhibiting topoisomerase-II. It can induce apoptosis and autophagy.
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Data Literature Source	[1]. Nitiss JL, et al. Targeting DNA topoisomerase II in cancer chemotherapy.Nat Rev Cancer. 2009 May; 9 (5) :338-50.[2]. Sadeghi-Aliabadi H, et al. Cytotoxic evaluation of doxorubicin in combination with simvastatin against human cancer cells. Res Pharm Sci. 2010 Jul; 5 (2) :127-33.[3]. El-Zawahry A, et al. Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancerxenografts. BMC Cancer. 2005 Jan 7; 5:2.[4]. Hayward R, et al. Doxorubicin cardiotoxicity in the rat: an in vivo characterization. J Am Assoc Lab Anim Sci. 2007 Jul; 46 (4) :20-32
Specification	10mg 50mg 10mM*1mL (in DMSO)