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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > EmodinCAS：518-82-1
Molecular Formula：C15H10O5
Molecular Weight：270.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Yellow to orange Solid
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| CAS | 518-82-1 |
| Name | Emodin |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.24 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | Yellow to orange Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-258-8 |
| MDL | MFCD00001207 |
| SMILES | O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O |
| InChIKey | RHMXXJGYXNZAPX-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3 |
| PubChem CID | 3220 |
| Target Point | Casein Kinase（CK） |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Stem Cells |
| Background | Emodin is a protein kinase CK2 inhibitor and an effective selective11 β- HSD1 inhibitor has a broad spectrum of anticancer activity. |
| Biological Activity | Emodin 是一种广谱抗癌剂。Emodin是一种Ser/Thr激酶，选择性地抑制酪蛋白激酶II（CKII）。大黄素抑制CKII活性，IC50为2μM。[1-3] |
| Data Literature Source | [1]. Yim H，et al. Emodin，an anthraquinone derivative isolated from the rhizomes of Rheum palmatum，selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 1999 Feb;65(1):9-13. [2]. Xing JY，et al. Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer CellsIn Vitro. PLoS One. 2015 Dec 18;10(12):e0144781. [3]. Li X，et al. Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. BMC Cancer. 2016 Aug 2;16:578 |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Zhang Q, et al. Oncol Rep. 2019 Oct;42(4):1589-1597.
Zhang Q, et al. Oncol Rep. 2019 Oct;42(4):1589-1597.
Zhou Q, et al. Pancreas. 2021 Sep 1;50(8):1202-1211.
Zhou Q, et al. Pancreas. 2021 Sep 1;50(8):1202-1211.
Zhou Q, et al. Pancreas. 2021 Sep 1;50(8):1202-1211.
Zhou Q, et al. Pancreas. 2021 Sep 1;50(8):1202-1211.
Sorry, there is no more information.
Aloe-emodin induces hepatotoxicity by the inhibition of multidrug resistance protein 2
Click to check >>Author：Liu DM; Yang D; Zhou CY; Wu JS; Zhang GL; Wang P; Wang F; Meng XL.
IF：7.9000
Publish_to：Phytomedicine
PMID：32028185
Computational and Experimental Studies Reveal That Thymoquinone Blocks the Entry of Coronaviruses Into In Vitro Cells
Click to check >>Author：Xu H; Liu B; Xiao Z; Zhou M; Ge L; Jia F; Liu Y; J
IF：5.4000
Publish_to：Infectious Diseases and Therapy
PMID：33532909
Emodin attenuates adenosine triphosphate?induced pancreatic ductal cell injury in vitro via the inhibition of the P2X7/NLRP3 signaling pathway
Click to check >>Author：Zhang Q; Hu F; Guo F; Zhou Q; Xiang H; Shang D
IF：4.1360
Publish_to：Oncol Rep
PMID：31524270
American ginseng with different processing methods ameliorate immunosuppression induced by cyclophosphamide in mice via the MAPK signaling pathways
Click to check >>Author：Juying Jiao, Jianjun Liu, Fei Luo, Mengxue Shang, Chen Pan, Bing Qi, Liang Zhao, Peiyuan Yin, Dong Shang
IF：3.8000
Publish_to：PHARMACEUTICAL BIOLOGY
PMID：37323024
Emodin Alleviates Intestinal Barrier Dysfunction by Inhibiting Apoptosis and Regulating the Immune Response in Severe Acute Pancreatitis
Click to check >>Author：Zhou Q; Xiang H; Liu H; Qi B; Shi X; Guo W; Zou J;
IF：2.9000
Publish_to：Pancreas
PMID：34714285
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