CAS |
490-46-0 |
Chinese Name |
表儿茶素 |
English Name |
(-)-Epicatechin |
Synonyms |
Epicatechin;(-)-Epicatechol;L-Epicatechin |
Molecular Formula |
C15H14O6 |
Molecular Weight |
290.27 |
Solubility |
Soluble in DMSO ≥10mg/mL |
Purity |
HPLC≥98% |
Appearance |
White to off-white Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC |
EINECS 207-710-1 |
MDL |
MFCD00075648 |
SMILES |
O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1 |
InChIKey |
PFTAWBLQPZVEMU-UKRRQHHQSA-N |
InChI |
InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1 |
PubChem CID |
72276 |
Target Point |
COX |
Passage |
Immunology & Inflammation |
Background |
(-)-Epicatechin inhibits COX-1; inhibits IL-1β-induced iNOS expression by blocking the nuclear localization of the p65 subunit of NF-κB. |
Biological Activity |
(-) -Epicatechin 抑制环加氧酶-1 (COX-1) , IC50为 3.2 μM。 (-) -Epicatechin 通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达[1-3]。 |
IC50 |
COX-1:3.2μM (IC50) [1-3] |
In Vitro |
(-)- 表儿茶素对环氧合酶-1(COX-1)在70μg/ mL时表现出> 95%的抑制活性,IC50为3.2μM[1]。(-)- 表儿茶素通过阻断NF-κB的p65亚基的核定位来抑制IL-1β诱导的iNOS表达。在RINm5F细胞中,(-)- 表儿茶素显示在加入IL-1β后阻断胰岛素释放的抑制。此外,(-)- 表儿茶素可抑制霍奇金淋巴瘤细胞和Jurkat T细胞的增殖,这归因于(-)- 表儿茶素抑制这些细胞中NF-κB与DNA结合的能力。在人结直肠癌HCT-116细胞中,将20μM人参二醇与150,200或250μM(-)- 表儿茶素组合,分别导致51%,97%和95%的生长抑制。通过膜联蛋白V / PI染色检查,该组合还使细胞凋亡水平增加了11.9%,16.6%和25.8%[2]。 |
In Vivo |
动物通过口服强饲法(每天两次)接受1mg / kg(-)- 表儿茶素或水(载体)。运动组进行15天的跑步机运动。(-)- 表儿茶素[3]观察到跑步机性能显着提高(~50%)和增强原位肌肉疲劳抗性(~30%)。 |
Animal Experiment |
将小鼠[3] 1岁,雄性C57BL / 6N小鼠(n = 25)随机分成四组。(-)- 表儿茶素组3和4中的小鼠每天两次(早晨和晚上)给予1.0mg / kg连续15天,而对照组1和2中的动物接受载体(水)。(-)- 表儿茶素和载体均通过口服强饲法给药[3]。 |
Data Literature Source |
[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001; 40 (2) :173-9. [2]. Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-) -Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015; 2015:181260. [3]. Nogueira L, et al. (-) -Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15; 589 (Pt 18) :4615-31. |
Unit |
Bottle |
Specification |
10mg 10mM*1mL in DMSO 100mg |