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Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > COX > Ginsenoside Rb3

Ginsenoside Rb3

CAS:68406-26-8

Appearance:White to off-white solid

Storage:Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months

Purity:HPLC≥98%

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Ginsenoside Rb3

Cat.No：

IG0200

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Solarbio

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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Product Information Related Products Related Paper COA Technical Q&A

Product Information

CAS	68406-26-8
Chinese Name	人参皂苷Rb3
English Name	Ginsenoside Rb3
Synonym	Gypenoside IV
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₅₃H₉₀O₂₂
Molecular Weight	1079.28
Appearance	White to off-white solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
MDL	MFCD10566396
SMILES	C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5CO)C)(CC[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO[C@H](OC[C@@H](O)[C@@H]8O)[C@@H]8O)([H])CC6)C
Description	Ginsenoside Rb3 has been reported to inhibit TNFα-induced NF-κB transcriptional activity in 293T cell line with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.
Target Point	NF-kB;COX-2;iNOS
Passage	NF-κB;Immunology & Inflammation
Data Literature Source	[1]. He F, et al. Antitumor effects of dammarane-type saponins from steamed Notoginseng. Pharmacogn Mag. 2014 Jul;10(39):314-7. [2]. Zhu JR, et al. Protective effects of ginsenoside Rb(3) on oxygen and glucose deprivation-induced ischemic injury in PC12 cells. Acta Pharmacol Sin. 2010 Mar;31(3):273-80. [3]. Huang G, et al. Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice. Sci Rep. 2017 Oct 2;7(1):12552
Specification	5mg 10mg 10mM*1mL (in DMSO)

据报道，在 293T 细胞系中 Ginsenoside Rb3 抑制 TNFα 诱导的 NF-κB 转录活性，IC50 为 8.2 μM。Ginsenoside Rb3 还抑制 COX-2 和 iNOS mRNA的诱导。

Remark：

These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.

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