Ginsenoside Rd_COX_Immunology & Inflammation_Inhibitors & Antagonists & Agonists_Small Molecule Compounds

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IG0220-5mg	Inquiry	Inquiry	Inquiry	Inquiry
IG0220-10mg	Inquiry	Inquiry	Inquiry	Inquiry
IG0220-1ml	Inquiry	Inquiry	Inquiry	Inquiry

CAS	52705-93-8
Chinese Name	人参皂苷Rd
English Name	Ginsenoside Rd
Synonym	Gypenoside VIII;Panaxoside Rd;Sanchinoside Rd
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₄₈H₈₂O₁₈
Molecular Weight	947.15
Appearance	White to off-white solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
MDL	MFCD00210508
EC	EINECS 258-118-5
InChIKey	RLDVZILFNVRJTL-IWFVLDDISA-N
InChI	InChI=1S/C48H82O18/c1-22(2)10-9-14-48(8，66-42-39(60)36(57)33(54)26(20-50)62-42)23-11-16-47(7)31(23)24(52)18-29-45(5)15-13-30(44(3，4)28(45)12-17-46(29，47)6)64-43-40(37(58)34(55)27(21-51)63-43)65-41-38(59)35(56)32(53)25(19-49)61-41/h10，23-43，49-60H，9，11-21H2，1-8H3/t23-，24+，25+，26+，27+，28-，29+，30-，31-，32+，33+，34+，35-，36-，37-，38+，39+，40+，41-，42-，43-，45-，46+，47+，48-/m0/s1
PubChem CID	11679800
SMILES	C[C@](CC/C=C(C)/C)([C@]1([H])[C@]([C@H](O)C[C@@]2([H])[C@@]3(C)CC[C@]4([H])[C@]2(C)CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@]6([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C4(C)C)([H])[C@@]3(C)CC1)O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O
Description	It inhibits TNFα-induced NF-κB transcriptional activity. Inhibits COX-2 and iNOS mRNA expression and also inhibits Ca2+ influx.
Target Point	NF-kB;COX-2;iNOS
Passage	NF-κB;Immunology & Inflammation
Data Literature Source	[1]. Song SB, et al. Inhibition of TNF-α-mediated NF-κB Transcriptional Activity in HepG2 Cells by Dammarane-type Saponins from Panax ginseng Leaves. J Ginseng Res. 2012 Apr;36(2):146-52. [2]. Lu C, et al. Inhibition of L-type Ca2+ current by ginsenoside Rd in rat ventricular myocytes. J Ginseng Res. 2015 Apr;39(2):169-77. [3]. Huang G, et al. Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice. Sci Rep. 2017 Oct 2;7(1):12552. [4]. Liu Y, et al. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci. 2006 Jun;91(2):356-64.
Specification	5mg 10mg 10mM*1mL (in DMSO)