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CAS:10238-21-8
Storage:Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity:HPLC≥98%
Appearance:White to off-white Solid
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It is a sulfonylurea compound that regulates insulin production, inhibits hepatic glycogenolysis and glycoconeogenesis by increasing portal vein insulin levels or acting directly on the liver, reducing liver production and output of glucose. It is a selective, ATP-sensitive inhibitor of potassium channels.
Examples of using this product（for reference only）
In Vivo:
Mice（Male C57BL/6 mice, 6–8 weeks of age and weighed 20–25g; 5 mg/kg glibenclamide, 1次/d，7d，I.P）:
Forty-eight mice that were 6–8 weeks of age and weighed 20–25 g were used for the study. The mice were injected intraperitoneally once a day for a week with 5 mg/kg glibenclamide (Solarbio, China), 15 mg/kg oridonin or the formulation vehicle of DMSO diluted with stroke-physiological saline solution. To minimize toxicity to mice, the final concentration of DMSO did not exceed 2%.
Reference：
Liu H, Gu C, Liu M, Liu G, Wang Y. NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury. Biochem Pharmacol. 2020 Jul;177:113998. doi: 10.1016/j.bcp.2020.113998. Epub 2020 Apr 27. PMID: 32353421.
