| CAS |
36051-31-7 |
| Chinese Name |
鸟苷-5'-三磷酸三钠盐 |
| English Name |
5'-GTP Trisodium Salt |
| Synonyms |
GTP Trisodium salt;5-鸟苷三磷酸三钠盐;Guanosine triphosphate |
| Molecular Formula |
C10H13N5O14P3Na3 |
| Molecular Weight |
589.13 |
| Solubility |
Soluble in Water ≥10mg/mL |
| Purity |
HPLC≥95% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 252-847-2 |
| MDL |
MFCD03787968 |
| SMILES |
O[C@@H]([C@H]([C@H](N1C=NC2=C1NC(N)=NC2=O)O3)O)[C@H]3COP(O)(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)=O |
| InChIKey |
KZRMTEVIDYXWQW-CYCLDIHTSA-K |
| InChI |
InChI=1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1 |
| PubChem CID |
135445727 |
| Target Point |
Others |
| Passage |
Others |
| Background |
5'-GTP Trisodium Salt is a G protein signal transduction activator， which can induce the release of exosomes containing guanoside molecules by upregulating the expression of miRNA (miR133a， miR133b) and myogenic regulatory factors. To promote myogenic cell differentiation， it has the potential to be used in biosynthesis and skeletal muscle regeneration. |
| Biological Activity |
The extracellular guanosine 5'-triphosphate， GTP， has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line.[1] |
| In Vitro |
Extracellular GTP(a)up-regulated miRNA(specifically miR133a and miR133b)and myogenic regulator factor and(b)induces human myogenic precursor cells to release exosomes stuffed with guanosine based molecules(mainly guanosine)in the extracellular milieu.[1] |
| Cell Experiment |
We tested GTP stimulus on human muscle precursor cells established in culture by human satellite cells derived from Vastus Lateralis of three young male.[1] |
| Data Literature Source |
[1]. Pietrangelo T，Di Filippo ES，Locatelli M，Piacenza F，Farina M，Pavoni E，Di Donato A，Innosa D，Provinciali M，Fulle S. Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine. Front Pharmacol. 2018 Mar 16;9:152. |
| Unit |
Bottle |
| Specification |
5mg 10mM*1mL in Water 10mg |
English
中文
Manual Download
