Harmine_DYRK_Protein Tyrosine Kinase/RTK _Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IH0010-20mg	Inquiry	Inquiry	Inquiry	Inquiry
IH0010-100mg	Inquiry	Inquiry	Inquiry	Inquiry
IH0010-1ml	Inquiry	Inquiry	Inquiry	Inquiry

CAS	442-51-3
Chinese Name	去氢骆驼蓬碱
English Name	Harmine
Synonym	Telepathine
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₁₃H₁₂N₂O
Molecular Weight	212.25
Appearance	Off-white to brown solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
EC	EINECS 207-131-4
MDL	MFCD00004958
InChIKey	BXNJHAXVSOCGBA-UHFFFAOYSA-N
InChI	InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
PubChem CID	5280953
SMILES	CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3
Description	It is a bi-specific tyrosine phosphorylated regulated kinase (DYRK) inhibitor with anti-cancer and anti-inflammatory activities. It has a high affinity for 5-HT2A serotonin receptor. PPARγ expression is regulated by inhibition of Wnt signaling pathway. It also selectively binds MAO-A and reversibly inhibits it.
Target Point	DYRK;PPARγ;5-HT Receptor;MAO-A
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease;Neuronal Signaling;GPCR & G Protein;Protein Tyrosine Kinase/RTK
Data Literature Source	[1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91.
Specification	20mg 10mM*1mL (in DMSO) 100mg