| CAS |
19685-09-7 |
| Chinese Name |
10-羟基喜树碱 |
| English Name |
(S)-10-Hydroxycamptothecin |
| Synonyms |
10-羟基喜树碱;伊立替康相关物质A;(S)-10-羟基喜树碱;Hydroxycamptothecine; |
| Molecular Formula |
C20H16N2O5 |
| Molecular Weight |
364.35 |
| Solubility |
Soluble in DMSO ≥10mg/mL |
| Purity |
HPLC≥98% |
| Appearance |
Light yellow to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 805-668-4 |
| MDL |
MFCD02093100 |
| SMILES |
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O |
| InChIKey |
HAWSQZCWOQZXHI-FQEVSTJZSA-N |
| InChI |
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1 |
| PubChem CID |
97226 |
| Target Point |
Topoisomerase |
| Passage |
DNA Damage/DNA Repair |
| Background |
(S)-10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor. Can significantly induce apoptosis, and can be used for the study of liver cancer, gastric cancer, colon cancer and leukemia. |
| Biological Activity |
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma， gastric carcinoma， colon cancer and leukaemia treatment[1-3]. |
| In Vitro |
(S)-10-Hydroxycamptothecin inhibits L1210 leukemia cells with an IC50 of 1.15 μM[1].(S)-10-Hydroxycamptothecin(5-20 μg/L; 6 days; Hep G2 cells)treatment results in the cell cycle arrest at G2/M phase[2].(S)-10-Hydroxycamptothecin induces differentiation，down-regulates nuclear antigen(PCNA)and up-regulates wild-type protein p53 in Hep G2 cells[2]. |
| In Vivo |
(S)-10-Hydroxycamptothecin(10-Hydroxycamptothecin)against L1210 leukemia in mice is tested. At the optimal dose(15 mg/kg)，(S)-10-Hydroxycamptothecin has a 71% increase in life span(ILS)[1]. |
| Data Literature Source |
[1]. Min Liu，et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting.
[2]. Min Liu，et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target，Early Online: 1–8
[3]. Yu P，et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35(8):1295-9. |
| Unit |
Bottle |
| Specification |
5mg 10mM*1mL in DMSO 10mg |
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