Irinotecan_Topoisomerase_DNA Damage & DNA Repai_Inhibitors & Antagonists & Agonists_Small Molecule Compounds

Biochemical Reagents

Antibiotics (Biochemical Reagents) Vitamins Carbohydrates and Derivatives Animal & Plant Hormones Surfactants Amino Acids & Peptides & Protein Enzymes & Coenzymes & Inhibitors Bases & Nucleic Acids & Derivatives Acids & Salts & Amines Biochemical Reagents Building Blocks PEG Derivatives

Protein and Immunity

Protein Extraction/Quantification Protein Electrophoresis Other Reagents Immunotechnical Services Recombinant Protein Whole Cell Protein

Small Molecule Compounds

Star Products Inhibitors & Antagonists & Agonists Peptides PROTAC Anti-Infection Plant Hormones Amino Acids & Derivatives Vitamins & Derivatives Carbohydrates & It's Analogues Cosolvent & Solubilizer Dye & Probe Reaction Substrate & Physicochemical Detection

Antibodies

Primary Antibodies Secondary Antibodies Loading Control Antibodies Label Antibodies Antigens Plant Antibodies Viral Antibodies Bacterial Antibodies Small Molecule Antibodies RNA Antibodies

ELISA

Human Rats Mice Other Species Antibody Pairs Self-Prepare Reagents

Biochemical Assay Kits

Micromethod Macromethod HPLC Anti-Reverse Series Oxidation Series Antioxidant Series Coenzyme Ⅰ Series Coenzyme Ⅱ Series Glycolysis Series Glutathione Series Vitamin C Metabolism Series ATP Series Nitrogen Metabolism Series Amino Acid Metabolism series Esterase Series Mitochondrial Respiratory Chain Series Tricarboxylic Acid Cycle Series Protease Series Fatty Acid Metabolism Series Starch Series Sucrose Series Sugar Metabolism Series Ion Series Soil Series Signal Series Transhydrogenase Series Other Series Protein quantification Pectin Series Photosynthesis Series Gluconeogenesis Series Vitamin Series

Standard References

Star Products Control Herbs Standard Solution CP Standards Imported Standards Standard References Derivatization Reagent Ion Pair Reagents Domestic Standard Material UV Spectroscopy Standards

Dye Reagents

Stain Solution Fixation Solution Dye

Cell Biology

Cell Detection Reagents Cell Growth Factor Cell Line Cell Culture Cell Isolation & Digestion Cell Staining & Probe Cell Transfection Limulus Lysate

Molecular Biology

Nucleic Acid Extraction/Purification PCR Nucleic Acid Electrophoresis Recombinant Clone Expression Molecular Hybridization

Chromatography Media

Fillers Prepacked Column

Microbial Culture

Strains Drug Sensi-Disc Culture Medium Others

Instruments & Consumables

Consumables Imported Consumables Pipette Instruments Consignment Products

Universal Buffer

Fermentation Products

Diagnostic Reagents

Magnetic Beads

Purified Magnetic Beads Immunoprecipitation Base Magnetic Beads

Nanomaterials

Graphite/Graphene Carbon Nanomaterials Molecular Sieve Other Nanomaterials Inorganic Nanomaterials Metallic Nanomaterial Graphenoid

Peptides

Substance P & Related Peptides Pituitary Adenylate Cyclase Activating Peptides Bag Cell Peptides Cholecystokinin RGD/RAD Peptides Opioid Peptides Cancer Research Apelin/APLN Viral-Associated Peptides Laminin Peptides Pituitary & Hypothalamic Hormone Melanocyte-Stimulating Hormone/MSH Adrenocorticotropic Hormone/ACTH Growth-Promoting Hormone Neuropeptides Thymopoietin & Thymosin Peptides Endothelin & It's Analogues Protein Kinases & Related Peptides Amyloid Peptides Multiple Sclerosis Peptide Tag Osteoporosis Research Matrix Metalloproteinase Substrate Hormones Calcitonin Antimicrobial Peptides Antioxidant Peptides Insect Neuropeptides Casein Morphine Peptides Enzyme Substrate Peptides Prolactin-Releasing Peptides Enkephalin Brain Natriuretic Peptides Endorphin & Endorphin Thrombin-Related Peptides Others Dynorphin Neurokinin Neuropeptides & Related Peptides Renal Myelin Peptides Growth Hormone & Growth Factor Somatostatin & It's Analogues Leptin Fragment Peptides Bombesin Gastrin Cell-Penetrating Peptides Fibronectin & Extracellular Matrix Peptides Anti-Inflammatory Peptides Natriuretic Peptides A Angiotensinogen Substrates & Inhibitors Angiopoietin & Angiotensin Bradykinin Thrombospondin Hematology Inflammation Research Allatostatins Inhibitor-Related Peptides Cosmetic Peptides

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
II0140-50mg	Inquiry	Inquiry	Inquiry	Inquiry
II0140-10mg	Inquiry	Inquiry	Inquiry	Inquiry
II0140-1ml	Inquiry	Inquiry	Inquiry	Inquiry

CAS	97682-44-5
Chinese Name	伊立替康
English Name	Irinotecan
Synonym	(+)-Irinotecan;Topotecin;CPT-11
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₃₃H₃₈N₄O₆
Molecular Weight	586.68
Appearance	Light yellow to yellow solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO≥10mg/ml
MDL	MFCD01862255
EC	EINECS 691-567-9
InChIKey	UWKQSNNFCGGAFS-XIFFEERXSA-N
InChI	InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
PubChem CID	60838
SMILES	O=C(N1CCC(N2CCCCC2)CC1)OC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3
Description	Irinotecan is a topoisomerase I inhibitor that prevents religation of DNA strands by binding to the topoisomerase I-DNA complex.
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Data Literature Source	[1]. Morales C, et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb; 56 (3) :219-26. [2]. Pavillard V, et al. Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. Cancer Chemother Pharmacol. 2002 Apr; 49 (4) :329-35. Epub 2002 Jan 30. [3]. Allegrini G, et al. Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice. Cancer Chemother Pharmacol. 2004 Mar; 53 (3) :261-6. Epub 2003 Dec 5. [4]. Dela Cruz FS, et al. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016 Oct 31; 8 (1) :116. [5]. Huang MY, et al. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. Apoptosis. 2016 Feb; 21 (2) :130-42.
Specification	10mg 10mM*1mL (in DMSO) 50mg