| CAS |
20784-50-3 |
| Chinese Name |
补骨脂乙素 |
| English Name |
Isobavachalcone |
| Synonyms |
4-Hydroxyisocordoim;异补骨脂查尔酮 |
| Molecular Formula |
C20H20O4 |
| Molecular Weight |
324.38 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
Light yellow to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD00902090 |
| SMILES |
O=C(/C=C/C1=CC=C(C=C1)O)C2=CC=C(C(C/C=C(C)\C)=C2O)O |
| InChIKey |
DUWPGRAKHMEPCM-IZZDOVSWSA-N |
| InChI |
InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+ |
| PubChem CID |
5281255 |
| Target Point |
AKT |
| Passage |
PI3K/Akt/mTOR |
| Background |
It has been reported to induce apoptosis in neuroblastoma. |
| Biological Activity |
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1]. |
| IC50 |
7.92μM(OVCAR-8 cell)[1] |
| In Vitro |
Isobavachalcone(6.0-48.0 μM; 72 hours; OVCAR-8，PC3，A549，MCF-7，L-02 and HUVEC cells)treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3，A549，MCF-7，L-02 and HUVEC cells growth with IC50 values of 15.06 μM，32.2 μM，28.29 μM，31.61 μM and 31.3 μM，respectively.Isobavachalcone(0-18 μM; 6 hours; OVCAR-8 and PC3 cells)treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation.Isobavachalcone(0-18 μM; 72 hours; OVCAR-8 and PC3 cells)treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway[1]. |
| In Vivo |
Isobavachalcone(20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice)treatment results in an increase in blood glucose levels，reaching a maximum within 1 hour and maintaining until 4 hours post-dosing[1]. |
| Data Literature Source |
[1]. Jing H，et al. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Lett. 2010 Aug 28;294(2):167-77. |
| Unit |
Bottle |
| Specification |
5mg 10mM*1mL in DMSO 10mg |
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