| CAS |
961-29-5 |
| Chinese Name |
异甘草素 |
| English Name |
Isoliquiritigenin |
| Synonyms |
GU17;ISL;SJ000286237 |
| Molecular Formula |
C15H12O4 |
| Molecular Weight |
256.25 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
Light yellow to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 607-884-2 |
| MDL |
MFCD00075907 |
| SMILES |
O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2 |
| InChIKey |
DXDRHHKMWQZJHT-FPYGCLRLSA-N |
| InChI |
InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+ |
| PubChem CID |
638278 |
| Target Point |
Aldose Reductase |
| Passage |
Metabolic Enzyme&Protease |
| Background |
Isoliquiritigenin is a flavonoid with antitumor activity that inhibits the activity of aldose reductase. |
| Biological Activity |
Isoliquiritigenin 是从光果甘草根中分到的黄酮类化合物, 具有抗肿瘤的活性, 能够抑制 aldose reductase 的活性, IC50 值为 320 nM[1-4]。 |
| IC50 |
IC50: 320nM (Aldose reductase) [1-4] |
| In Vitro |
异甘草素可通过抑制大鼠晶状体醛糖还原酶预防糖尿病并发症，IC50为320 nM，山梨醇在人红细胞中积聚，IC50为2.0μM[1]。异甘草素(100μM)显着抑制缺氧诱导的心肌细胞TPS和TR90延长。与载体组相比，异甘草素显着触发AMPK Thr172磷酸化。异甘草素处理还诱导心肌细胞中的细胞外信号调节激酶(ERK)信号传导途径。异甘草素处理显着降低缺氧/复氧期间分离的心肌细胞的细胞内ROS水平[3]。异甘草素不仅可以下调IL-6的表达，还可以显着降低磷酸化ERK和STAT3的水平，并且可以抑制重组人IL-6诱导的ERK和STAT3的磷酸化水平，重组人IL-6是IL-6信号调节网络中的关键信号蛋白[4]。 |
| In Vivo |
异甘草素显示由各种类型的兴奋剂如CCh(1 mM)，KCl(60 mM)和BaCl 2(0.3 mM)诱导的小鼠空肠强直收缩的浓度依赖性抑制，IC50值为4.96±1.97 mM，4.03±1.34分别为mM和3.70±0.58 mM [2]。异甘草素在MM异种移植模型中显示出显着的抗肿瘤活性，并协同增强阿霉素的抗骨髓瘤活性[4]。 |
| Data Literature Source |
[1]. Aida K， et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun; 56 (3) :254-8.
[2]. Sato Y， et al. Isoliquiritigenin， one of the antispasmodic principles of Glycyrrhiza ularensis roots， acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan; 30 (1) :145-9.
[3]. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013; 2013:390890.
[4]. Chen X， et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl) . 2012 Nov; 90 (11) :1311-9. |
| Unit |
Bottle |
| Specification |
10mg 10mM*1mL in DMSO 20mg |
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