Ivermectin_Anti-Parasite_Anti-Infection_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	70288-86-7
Chinese Name	依维菌素
English Name	Ivermectin
Synonym	MK-933
Unit	Bottle
Purity	≥98%
Molecular Formula	C₄₈H₇₄O₁₄
Molecular Weight	875.11
Appearance	White to off-white solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO
EC	EINECS 274-536-0
InChIKey	AZSNMRSAGSSBNP-XPNPUAGNSA-N
InChI	InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
PubChem CID	6321424
SMILES	CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@H](/C(C)=C/C[C@@H]3C[C@H]4C[C@@]5(O[C@]([H])(C(C)C)[C@@H](C)CC5)O3)[C@@H](C)/C=C/C=C6CO[C@@]7([H])[C@]\6(O)[C@H](C(O4)=O)C=C(C)[C@H]7O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O.CO[C@H]8C[C@H](O[C@H]9[C@H](C)O[C@@H](O[C@H](/C(C)=C/C[C@@H]%10C[C@H]%11C[C@@]%12(O[C@]([H])([C@@H](C)CC)[C@@H](C)CC%12)O%10)[C@@H](C)/C=C/C=C%13CO[C@@]%14([H])[C@]\%13(O)[C@H](C(O%11)=O)C=C(C)[C@H]%14O)C[C@@H]9OC)O[C@@H](C)[C@@H]8O
Description	Ivermectin is a broad-spectrum antiparasitic compound with anti-HIV-1, SARS-CoV-2 and dengue virus activities. Ivermectin is a specific Imp α/β 1-mediated nuclear induction inhibitors and P2X4 and α 7 nAChRs, a positive isomeric effector.
Target Point	Parasite;HIV;Mitophagy;HSV;SARS-CoV
Passage	Anti-infection
Data Literature Source	[1]. Khakh BS, et al. Allosteric control of gating and kinetics at P2X (4) receptor channels. J Neurosci. 1999 Sep 1; 19 (17) :7289-99. [2]. Priel A, et al. Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol. 2004 Mar; 123 (3) :281-93. [3]. Krause RM, et al. Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol. 1998 Feb; 53 (2) :283-94. [4]. Adelsberger H, et al. Activation of rat recombinant alpha (1) beta (2) gamma (2S) GABA (A) receptor by the insecticide ivermectin. Eur J Pharmacol. 2000 Apr 14; 394 (2-3) :163-70.
Specification	100mg 10mM*1mL (in DMSO) 500mg