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My CartCAS：70288-86-7
Molecular Formula：C48H74O14
Molecular Weight：875.11
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 70288-86-7 |
| Name | Ivermectin |
| Molecular Formula | C48H74O14 |
| Molecular Weight | 875.11 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 274-536-0 |
| SMILES | CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@H](/C(C)=C/C[C@@H]3C[C@H]4C[C@@]5(O[C@]([H])(C(C)C)[C@@H](C)CC5)O3)[C@@H](C)/C=C/C=C6CO[C@@]7([H])[C@]\6(O)[C@H](C(O4)=O)C=C(C)[C@H]7O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O.CO[C@H]8C[C@H](O[C@H]9[C@H](C)O[C@@H](O[C@H](/C(C)=C/C[C@@H]%10C[C@H]%11C[C@@]%12(O[C@]([H])([C@@H](C)CC)[C@@H](C)CC%12)O%10)[C@@H](C)/C=C/C=C%13CO[C@@]%14([H])[C@]\%13(O)[C@H](C(O%11)=O)C=C(C)[C@H]%14O)C[C@@H]9OC)O[C@@H](C)[C@@H]8O |
| InChIKey | AZSNMRSAGSSBNP-XPNPUAGNSA-N |
| InChI | InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1 |
| PubChem CID | 6321424 |
| Target Point | Parasite;HIV;Mitophagy;HSV;SARS-CoV |
| Passage | Anti-infection |
| Background | Ivermectin is a broad-spectrum antiparasitic compound with anti-HIV-1, SARS-CoV-2 and dengue virus activities. Ivermectin is a specific Imp α/β 1-mediated nuclear induction inhibitors and P2X4 and α 7 nAChRs, a positive isomeric effector. |
| Biological Activity | Ivermectin是广泛使用于人类和动物的抗寄生虫剂。它是P2X4和α7 nAChRs的正异构效应物。[1-4] |
| Data Literature Source | [1]. Khakh BS， et al. Allosteric control of gating and kinetics at P2X (4) receptor channels. J Neurosci. 1999 Sep 1; 19 (17) :7289-99. [2]. Priel A， et al. Mechanism of ivermectin facilitation of human P2X4 receptor channels. J Gen Physiol. 2004 Mar; 123 (3) :281-93. [3]. Krause RM， et al. Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol. 1998 Feb; 53 (2) :283-94. [4]. Adelsberger H， et al. Activation of rat recombinant alpha (1) beta (2) gamma (2S) GABA (A) receptor by the insecticide ivermectin. Eur J Pharmacol. 2000 Apr 14; 394 (2-3) :163-70. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Can Ivermectin kill Sarcoptes scabiei during the molting process?
Click to check >>Author：Shenrui Feng, Minmin Shi, Zhijuan Yin, Wenda Di, Jacques Guillot, Fang Fang
IF：4.7810
Publish_to：PLoS Neglected Tropical Diseases
PMID：37196006
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