CAS |
58749-22-7 |
Chinese Name |
甘草查尔酮A |
English Name |
Licochalcone A |
Synonym |
Licochalcone-A |
Unit |
Bottle |
Purity |
HPLC≥98% |
Molecular Formula |
C21H22O4 |
Molecular Weight |
338.4 |
Appearance |
Solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO |
MDL |
MFCD01417903 |
EC |
EINECS 635-678-2 |
InChIKey |
KAZSKMJFUPEHHW-DHZHZOJOSA-N |
InChI |
InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+ |
PubChem CID |
5318998 |
SMILES |
O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC |
Description |
It is a flavonoid with anticancer, antibacterial and antiviral activities. |
Passage |
Others |
IC50 |
Licochalcone A, an oxygenated chalcone isolated from the roots of Chinese licorice plant, inhibited the growth of both Leishmania major and Leishmania donovani promastigotes and amastigotes. [2]The vegetative cell growth of Bacillus subtilis was inhibited in a licochalcone A concentration-dependent manner and was completely prevented by 3 micrograms of licochalcone A/ml. Licochalcone A showed a high level of resistance to heating at 80 to 121 degrees C for 15 min. Licochalcone A did not inhibit the germination of heat-treated spores of B. subtilis induced by L-alanine. Licochalcone A showed effects against all gram-positive bacteria tested and especially was effective against all Bacillus spp.[3] |
Data Literature Source |
[1]. Chen M, Christensen SB, Theander TG, Kharazmi A. Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani. Antimicrob Agents Chemother. 1994 Jun;38(6):1339-44.
[2]. Chen M, Christensen SB, Blom J, Lemmich E, Nadelmann L, Fich K, Theander TG, Kharazmi A. Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrob Agents Chemother. 1993 Dec;37(12):2550-6.
[3]. Tsukiyama R, Katsura H, Tokuriki N, Kobayashi M. Antibacterial activity of licochalcone A against spore-forming bacteria. Antimicrob Agents Chemother. 2002 May;46(5):1226-30. |
Specification |
5mg 10mM*1mL in DMSO 10mg |