Naringin_Cytochrome P450_Metabolic Enzyme & Protease_Inhibitors & Antagonists & Agonists_Small Molecule Compounds

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
IN0080-1ml	Inquiry	Inquiry	Inquiry	Inquiry
IN0080-10mg	Inquiry	Inquiry	Inquiry	Inquiry
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CAS	10236-47-2
Chinese Name	柚皮苷
English Name	Naringin
Synonym	柚皮苷;柚苷;柑橘甙;异橙皮甙;
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₂₇H₃₂O₁₄
Molecular Weight	580.53
Appearance	White to yellow solid
Storage	Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO≥10mg/ml, soluble in water<1mg/ml
EC	EINECS 233-566-4
MDL	MFCD00148888
InChIKey	DFPMSGMNTNDNHN-ZPHOTFPESA-N
InChI	InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
PubChem CID	442428
SMILES	O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@@]5([H])[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13
Description	Naringin is a flavanone glycoside with many biological activities, which can be used for researches on antioxidant activity, blood lipid lowering, anticancer, and inhibition of cytochrome P450 enzymes.
Target Point	Cytochrome P450
Passage	Metabolic Enzyme&Protease
IC50	IC50: 9026 uM (p450) [1-4]
Data Literature Source	[1]. Chen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30; 10 (11) :e0143868. [2]. Raha S, et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep; 47 (3) :1061-9. [3]. Kulasekaran G, et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov; 409 (1-2) :199-211. [4]. Wang D, et al. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cell Mol Neurobiol. 2015 Oct; 35 (7) :1061-71
Specification	10mg 50mg 10mM*1mL (in DMSO)