CAS |
1405-10-3 |
Chinese Name |
硫酸新霉素 |
English Name |
Neomycin Sulfate |
Synonyms |
硫酸新霉素;AD-5423;硫酸新霉素;Neomycin sulphate |
Molecular Formula |
C23H52N6O25S3 |
Molecular Weight |
908.88 |
Solubility |
Soluble in Water ≥50mg/mL |
Purity |
≥98% |
Appearance |
White to yellow Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC |
EINECS 215-773-1 |
MDL |
MFCD00037007 |
SMILES |
O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4] |
InChIKey |
OIXVKQDWLFHVGR-WQDIDPJDSA-N |
InChI |
InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 |
PubChem CID |
197162 |
Target Point |
Bacterial;Phospholipase C (PLC) |
Passage |
Metabolic Enzyme&Protease; Anti-infection |
Background |
It is an aminoglycoside antibiotic that exerts antibacterial activity through irreversible binding of nuclear 30S ribosomal subunits, thereby blocking the synthesis of bacterial proteins, and is often used to screen prokaryotic and eukaryotic cells with Neo resistance genes. |
Biological Activity |
Neomycin sulfate是用于预防或治疗 细菌 感染的氨基糖苷类抗生素。[1-4] |
Data Literature Source |
[1]. Carney,D.H.,et al. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Cell,1985. 42(2): p. 479-88. [2]. Nakashima,S.,et al. Neomycin is a potent agent for arachidonic acid release in human platelets. Biochem Biophys Res Commun,1987. 146(2): p. 820-6. [3]. Liscovitch,M.,et al.,Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem J,1991. 279 ( Pt 1): p. 319-21. [4]. Huang K,et al. CRAC channel is inhibited by neomycin in a Ptdlns(4,5)P2-independent manner. Cell Biochem Funct. 2015 Mar;33(2):97-100 |
Unit |
Bottle |
Specification |
200mg 10mM*1mL in Water 500mg 1g 5g |