Nystatin_Anti-Fungal_Anti-Infection_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

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CAS	1400-61-9
Chinese Name	制霉菌素
English Name	Nystatin
Synonym	制霉菌素; Nystavescent; Fungicidin; Stamycin
Unit	Bottle
Purity	≥98%
Molecular Formula	C₄₇H₇₅NO₁₇
Molecular Weight	926.09
Appearance	Yellow to yellowish brown solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO≥10mg/ml
MDL	MFCD00036240
EC	EINECS 215-749-0
InChIKey	VQOXZBDYSJBXMA-RKEBNKJGSA-N
InChI	InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1
PubChem CID	6433272
SMILES	C[C@@H]1OC(C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@@](O)(O[C@H]2C[C@H](/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]([C@@H](O)[C@H]1C)C)O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C[C@H](O)[C@H]2C(O)=O)=O
Description	Nystatin is a potent polyene antifungal antibiotic that is effective against yeast and mycoplasma. It is also a cholesterol isolator that partially prevents Oxaliplatin induced lipid raft aggregation, DR4 and DR5 aggregation, thereby reducing apoptosis.
Target Point	Fungal
Passage	Anti-infection
Data Literature Source	[1]. Ellepola AN, et al. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999 Dec; 14 (6) :358-63. [2]. Haas M, et al. Na-K-Cl cotransport in nystatin-treated tracheal cells: regulation by isoproterenol, apical UTP, and [Cl]i. Am J Physiol. 1994 May; 266 (5 Pt 1) :C1440-52. [3]. Chen Y, et al. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9; 117 (23) :6392-403 [4]. Wallace TL, et al. Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice. Antimicrob Agents Chemother. 1997 Oct; 41 (10) :2238-43
Specification	100mg 10mM*1mL (in DMSO) 500mg