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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > OxaliplatinCAS：61825-94-3
Molecular Formula：C8H14N2O4Pt
Molecular Weight：397.29
Storage：Powder:2-8℃，2 years
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 61825-94-3 |
| Name | Oxaliplatin |
| Molecular Formula | C8H14N2O4Pt |
| Molecular Weight | 397.29 |
| Solubility | Soluble in DMF ≥4mg/mL(* This product is not stable in solution, it is recommended that you use it now) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| EC | EINECS 621-248-1 |
| MDL | MFCD00866327 |
| SMILES | O=C1[O-][Pt+2]2([NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]2)[O-]C1=O |
| InChIKey | DRMCATBEKSVAPL-BNTLRKBRSA-N |
| InChI | InChI=1S/C6H12N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-8H,1-4H2;(H,3,4)(H,5,6);/q-2;;+2/t5-,6-;;/m1../s1 |
| PubChem CID | 9887053 |
| Target Point | Autophagy;DNA/RNA Synthesis |
| Passage | Autophagy;Cell Cycle;DNA Damage/DNA Repair |
| Background | Oxaliplatin is a DNA synthesis inhibitor that causes DNA cross-linking damage， prevents DNA replication and transcription and leads to cell death， which can induce autophagy. |
| Biological Activity | Oxaliplatin是一种 DNA 合成 抑制剂。 它会导致DNA交联损伤，阻止DNA复制和转录并导致细胞死亡。[1-7] |
| Data Literature Source | [1]. Raymond E，et al. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol. 1998 Oct;9(10):1053-71. [2]. Mohammed MQ，et al. Oxaliplatin is active in vitro against human melanoma cell lines: comparison with cisplatin and carboplatin. Anticancer Drugs. 2000 Nov;11(10):859-63. [3]. Pendyala L，et al. In vitro cytotoxicity，protein binding，red blood cell partitioning，and biotransformation of oxaliplatin. Cancer Res. 1993 Dec 15;53(24):5970-6. [4]. Wang Z，et al. Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth. Expert Opin Investig Drugs. 2009 Nov;18(11):1595-604 [5]. Mathé G，et al. Oxalato-platinum or 1-OHP，a third-generation platinum complex: an experimental and clinical appraisal and preliminary comparison with cis-platinum and carboplatinum. Biomed Pharmacother. 1989;43(4):237-50. [6]. Schellingerhout D，et al. Impairment of retrograde neuronal transport in oxaliplatin-induced neuropathy demonstrated by molecular imaging. PLoS One. 2012;7(9):e45776. doi: 10.1371/journal.pone.0045776. Epub 2012 Sep 20. [7]. Romero HK，et al. Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1825-E1832. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Zhang Y, et al. Asian J Pharm Sci. 2023 May;18(3):100801.
Zhang Y, et al. Asian J Pharm Sci. 2023 May;18(3):100801.
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Treatment of colorectal cancer by anticancer and antibacterial effects of hemiprotonic phenanthroline-phenanthroline+ with nanomicelle delivery
Click to check >>Author：Zhang Y, Zhao Z, Li J, Wang Q, Fan Z, Yuan Z, Feng Y, Fu A.
IF：10.2000
Publish_to：Asian J Pharm Sci
PMID：37274926
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