| CAS |
14937-32-7 |
| Chinese Name |
1,2,3,4,6-O-没食子酰葡萄糖 |
| English Name |
1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose |
| Synonyms |
Penta-O-galloyl-β-D-glucose;1，2，3，4，6-O-五没食子酰葡萄糖 |
| Molecular Formula |
C41H32O26 |
| Molecular Weight |
940.68 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 604-691-5 |
| MDL |
MFCD03788860 |
| SMILES |
O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]([C@@H]([C@@H](COC(C2=CC(O)=C(O)C(O)=C2)=O)O3)OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@H]([C@@H]3OC(C5=CC(O)=C(O)C(O)=C5)=O)OC(C6=CC(O)=C(O)C(O)=C6)=O |
| InChIKey |
QJYNZEYHSMRWBK-NIKIMHBISA-N |
| InChI |
InChI=1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33-,34+,35-,41+/m1/s1 |
| PubChem CID |
65238 |
| Target Point |
Others |
| Passage |
Others |
| Background |
It has a variety of important pharmacological effects and can be used to precipitate proteins. |
| Biological Activity |
1，2，3，4，6-penta-O-galloyl-β-D-glucopyranose (PGG) is a gallotannin isolated from various plants. The inhibitory effect of PGG on IgE production could be partially caused by increasing a population of Treg cells in conjunction with Treg-inducing factors.[1] |
| Animal Experiment |
Mice orally administered PGG showed a decrease in total and OVA-specific IgE levels in serum. Oral administration of PGG strongly suppressed production of type 2 T helper(IL-4 and IL-13)，type 1 T helper(IFN-γ)，and pro-inflammatory cytokines(TNF-α and IL-6)，but not anti-inflammatory cytokine(IL-10)from splenocytes of OVA-sensitized mice against OVA re-stimulation. A population of T regulatory(Treg)cells with immunosuppressive properties was increased in mesenteric lymph nodes and spleen of PGG-fed mice. PGG administration not only reduced expression levels of eotaxin，tissue inhibitors of metalloproteinases-1，and TNF-α，which assisted with IgE production，but also increased the expression of insulin-like growth factor binding protein-3 which inhibits IgE production. Additionally，PGG increased the levels of Treg cell-inducing factors such as IL-2，IL-10 and platelet factor-4 in serum.[1] |
| Data Literature Source |
[1]. Kim YH，et al. 1，2，3，4，6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Int Immunopharmacol. 2015 May;26(1):30-6. |
| Unit |
Bottle |
| Specification |
5mg 10mg 10mM*1mL in DMSO |
English
中文
Manual Download
