| CAS |
36322-90-4 |
| Chinese Name |
吡罗昔康 |
| English Name |
Piroxicam |
| Synonyms |
CP-16171 |
| Molecular Formula |
C15H13N3O4S |
| Molecular Weight |
331.35 |
| Solubility |
Soluble in DMSO |
| Purity |
≥98% |
| Appearance |
Light yellow to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 252-974-3 |
| MDL |
MFCD00057317 |
| SMILES |
O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=CC=C3 |
| InChIKey |
QYSPLQLAKJAUJT-UHFFFAOYSA-N |
| InChI |
InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) |
| PubChem CID |
54676228 |
| Target Point |
COX |
| Passage |
Immunology & Inflammation |
| Background |
Piroxicam is a non-steroidal anti-inflammatory agent that inhibits COX activity |
| Biological Activity |
Piroxicam 是一种非甾体抗炎剂，能够抑制 COX 的活性，对人单核细胞 COX-1 和 COX-2 的 IC50 值分别为 47 和 25 μM。[1-3] |
| In Vitro |
Piroxicam(167，333，500μM)减少T24和5637细胞的细胞群。吡罗昔康(500μM)也降低了T24和5637细胞的细胞活力，并且当与0.05μM卡铂组合时显著有效。该组合还抑制了展位细胞中Ki-67的表达[3]。 |
| In Vivo |
Piroxicam(0.3 mg/kg qd 24-h po)可降低18只狗中12只的肿瘤体积，这种效果是通过诱导细胞凋亡和降低尿液碱性成纤维细胞生长因子浓度来实现的[2]。 |
| Cell Experiment |
用分级浓度的卡铂(0.05，0.5和1μM)和吡罗昔康(167，333和500μM)处理膀胱癌细胞系72小时以评估剂量 - 反应谱。对于组合方法，使用0.05μM卡铂和333μM吡罗昔康。在每次实验之前，两种药物都是新鲜制备的。未处理的对照组(未暴露于卡铂和吡罗昔康的细胞)用于所有测定[3]。 |
| Animal Experiment |
狗[2]狗在治疗前和吡罗昔康(0.3 mg/kg qd 24-h po)治疗4周后接受肿瘤分期，包括胸部和腹部X线摄影，膀胱造影，超声检查和膀胱镜检查(收集组织样本)。在吡罗昔康治疗的4周期间，狗没有接受任何其他癌症治疗[2]。 |
| Data Literature Source |
[1]. Kato M，et al. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol. 2001 Dec;53(12):1679-85.
[2]. Mohammed SI，et al. Effects of the cyclooxygenase inhibitor，piroxicam，on tumor response，apoptosis，and angiogenesis in a canine model of human invasive urinary bladder cancer. Cancer Res. 2002 Jan 15;62(2):356-8.
[3]. Silva J，et al. Synergistic Effect of Carboplatin and Piroxicam on Two Bladder Cancer Cell Lines. Anticancer Res. 2017 Apr;37(4):1737-1745 |
| Unit |
Bottle |
| Specification |
50mg 10mM*1mL in DMSO 100mg 500mg |
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