CAS |
34080-08-5 |
Chinese Name |
原人参三醇 |
English Name |
(20S)-Protopanaxatriol |
Synonyms |
g-PPT;20(S)-APPT;20(S)-原人参三醇 |
Molecular Formula |
C30H52O4 |
Molecular Weight |
476.73 |
Solubility |
Soluble in DMSO |
Purity |
HPLC≥98% |
Appearance |
White to off-white Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL |
MFCD11041271 |
SMILES |
C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O)[C@@]2([H])C3(C)C)[C@]4([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC4)C |
InChIKey |
SHCBCKBYTHZQGZ-CJPZEJHVSA-N |
InChI |
InChI=1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3/t19-,20+,21-,22+,23-,24-,25-,27+,28+,29+,30-/m0/s1 |
PubChem CID |
11468733 |
Target Point |
Glucocorticoid Receptor (GR, or GCR) |
Passage |
GPCR & G Protein |
Background |
It is a metabolite of ginsenoside, acts through glucocorticoid receptor and oestrogen receptor, and is an inhibitor of LXRα. |
Biological Activity |
(20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptor 和 oestrogen receptor 起作用,同时为 LXRα 的抑制剂。[1-2] |
In Vitro |
(20S)-Protopanaxatriol通过人脐静脉内皮细胞(HUVEC)中的糖皮质激素受体(GR)和雌激素受体(ER)起作用。(20S)-Protopanaxatriol(g-PPT)在HUVEC中增加[Ca2 +] i,EC50为482nM。(20S)-Protopanaxatriol(1μM)通过ERβ提高NO产生[1]。(20S)-Protopanaxatriol(PPT)抑制Gal4-LXRαLBD的自主反式激活,这是T0901317依赖的SREBP-1c及其启动子的转录。(20S)-Protopanaxatriol(10μg/ mL)阻断RNA聚合酶II向SREBP-1c的LXRE区域的募集。(20S)-Protopanaxatriol还抑制与脂肪生成相关的LXRα靶基因的T0901317依赖性转录,并减少T0901317诱导的原代肝细胞中的细胞甘油三酯(TG)积累,但不改变ABCA1的转录,也是LXRα靶基因的转录[2] 。 |
Data Literature Source |
[1]. Leung KW, et al. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb; 156 (4) :626-37. [2]. Oh GS, et al. 20 (S) -protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun; 128 (2) :71-7. |
Unit |
Bottle |
Specification |
10mg 10mM*1mL in DMSO 20mg |