CAS |
139755-83-2 |
Chinese Name |
西地那非 |
English Name |
Sildenafil |
Synonym |
Chlorphenaminemaleate |
Unit |
Bottle |
Purity |
≥98% |
Molecular Formula |
C22H30N6O4S |
Molecular Weight |
474.58 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO≥30mg/ml |
MDL |
MFCD00867528 |
EC |
EINECS 200-659-6 |
InChIKey |
BNRNXUUZRGQAQC-UHFFFAOYSA-N |
InChI |
InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) |
PubChem CID |
135398744 |
SMILES |
O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1 |
Description |
Sildenafil is a phosphodiesterase 5 (PDE-5) inhibitor |
Target Point |
Phosphodiesterase (PDE) |
Passage |
Metabolic Enzyme&Protease |
IC50 |
IC50: 5.22 nM (PDE 5) [1] |
Data Literature Source |
[1]. Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov; 10 (11) :2790-7.
[2]. Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep; 124 (17) :2733-40.
[3]. Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28; 13 (1) :95.
[4]. Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar; 33 (2) :204-11. |
Specification |
50mg 10mM*1mL (in DMSO) 100mg 200mg |