CAS |
79902-63-9 |
Chinese Name |
辛伐他汀 |
English Name |
Simvastatin |
Synonym |
MK 733 |
Unit |
Bottle |
Purity |
HPLC≥98% |
Molecular Formula |
C25H38O5 |
Molecular Weight |
418.57 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO/Ethanol ≥5mg/mL |
MDL |
MFCD00072007 |
EC |
EINECS 404-520-2 |
InChIKey |
RYMZZMVNJRMUDD-HGQWONQESA-N |
InChI |
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 |
PubChem CID |
54454 |
SMILES |
CCC(C)(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O |
Description |
Simvastatin is a competitive HMG-CoA reductase inhibitor. |
Target Point |
HMG-CoA Reductase (HMGCR) |
Passage |
Metabolic Enzyme&Protease |
IC50 |
Ki: 0.2 nM (HMG-CoA reductase) [1] |
Data Literature Source |
[1]. Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.
[2]. Kureishi, Y., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med, 2000. 6 (9) : p. 1004-10.
[3]. Leung BP, et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol. 2003 Feb 1; 170 (3) :1524-30.
[4]. Kobayashi M, et al. Preventive effect of MK-733 (simvastatin) , an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits. Jpn J Pharmacol. 1989 Jan; 49 (1) :125-33.
[5]. Ishida F, et al. Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits. Biochim Biophys Acta. 1990 Feb 23; 1042 (3) :365-73.
[6]. Sukhova GK, et al. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1; 22 (9) :1452-8.
[7]. Weijiang Dong, et al. Differential effects of simvastatin and pravastatin on expression of Alzheimer’s disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct; 50 (10) : 2095-2102.
[8]. Liu Z, et al. Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat. Oxid Med Cell Longev. 2017; 2017:3861914 |
Specification |
100mg 10mM*1mL (in DMSO) 200mg |