Sorafenib_Raf_MAPK_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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Chemical Synthesis

SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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CAS	284461-73-0
Chinese Name	索拉非尼
English Name	Sorafenib
Synonym	;Nexavar;Bay43-9006;索拉非尼;Raf抑制剂;
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₂₁H₁₆ClF₃N₄O₃
Molecular Weight	464.83
Appearance	White to off-white solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in DMSO≥5mg/ml
EC	EINECS 608-209-4
MDL	MFCD06411450
InChIKey	MLDQJTXFUGDVEO-UHFFFAOYSA-N
InChI	InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
PubChem CID	216239
SMILES	O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Description	It is a potent Raf inhibitor and a multi-kinase inhibitor, which has inhibitory effect on VEGFR2,VEGFR3,PDGFRβ,FLT3 and c-Kit. It was also a ferroptosis agonist that induced autophagy and apoptosis.
Target Point	Ferroptosis;Raf
Passage	Apoptosis;MAPK
Data Literature Source	[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109. [2]. El-Ashmawy NE, et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16. [3]. Jin W, et al. Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1. Oncol Rep. 2017 Jan;37(1):273-280. [4]. Li M, et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017 Aug 29.
Specification	10mg 10mM*1mL (in DMSO) 50mg 100mg