{{cart_num}}
My CartCAS：154-42-7
Molecular Formula：C5H5N5S
Molecular Weight：167.19
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
Qty：
Size：
| CAS | 154-42-7 |
| Name | 6-Thioguanine |
| Molecular Formula | C5H5N5S |
| Molecular Weight | 167.19 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-827-2 |
| MDL | MFCD00233553 |
| SMILES | SC1=NC(N)=NC2=C1N=CN2 |
| InChIKey | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
| InChI | InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) |
| PubChem CID | 2723601 |
| Target Point | Influenza Virus(SARS-CoV) |
| Passage | Anti-infection |
| Background | 6-Thioguanine is an immunosuppressant and an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros), and can effectively inhibit the activity of USP2. Can be used for anti-leukemia related research. |
| Biological Activity | 6-Thioguanine 是一种抗白血病和免疫抑制剂, 为 SARS 和 MERS 冠状病毒木瓜样蛋白酶 (PLpros) 的抑制剂, 同时可有效抑制 USP2 的活性, IC50 值分别为 25 μM 和 40 μM[3]。 |
| IC50 | IC50: 25μM (PLpros) ， 40μM (Recombinant human USP2) [3] |
| Data Literature Source | [1]. Chuang SJ， et al. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. Sci Rep. 2018 Feb 15; 8 (1) :3102. [2]. Wang H， et al. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry. 2009 Mar 17; 48 (10) :2290-9. [3]. LaDuke KE， et al. Effects of azathioprine， 6-mercaptopurine， and 6-thioguanine on canine primary hepatocytes. Am J Vet Res. 2015 Jul; 76 (7) :649-55 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
