CAS |
1069-66-5 |
Chinese Name |
丙戊酸钠 |
English Name |
Valproic acid Sodium Salt |
Synonym |
丙戊酸钠;2-丙基戊酸钠;敌白痉; |
Unit |
Bottle |
Purity |
GC≥97% |
Molecular Formula |
C8H15NaO2 |
Molecular Weight |
166.19 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in water≥50mg/ml, soluble in DMSO≥4mg/ml |
MDL |
MFCD00078604 |
EC |
EINECS 213-961-8 |
InChIKey |
AEQFSUDEHCCHBT-UHFFFAOYSA-M |
InChI |
InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1 |
PubChem CID |
16760703 |
SMILES |
[O-]C(C(CCC)CCC)=O.[Na+] |
Description |
It is an HDAC inhibitor that inhibits the activity of HDAC1 and induces the degradation of HDAC2. It can be used for research in epilepsy, bipolar disorder and migraine. |
Target Point |
HDAC |
Passage |
DNA Damage/DNA Repair;Epigenetics |
Data Literature Source |
[1]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005.
[2]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.
[3]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50.
[4]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10.
[5]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. |
Specification |
50mg 10mM*1mL (in DMSO) 10mM*1mL in Water 100mg |