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5-Quinoxilin-6-Methylene-1, 3-Thiazolidine-2, 4-Dione (As605240) (Pi3-K Gamma Inhibitor 1)
CAS:648450-29-7
5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione (AS605240) is an ATP-competitive inhibitor of PI3-Kγ (IC50 = 8 nM). It is selective for the γ-isoform (IC50: PI 3-Kα = 60 nM, PI 3-Kβ = 270 nM, PI 3-Kδ = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 μM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus.
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