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5-(2, 2-Difluoro-Benzo[1, 3]Dioxol-5-Ylmethylene)-Thiazolidine-2, 4-Dione (As604850)(Pi3-K Gamma Inhibitor 2)
CAS:648449-76-7
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-Kγ with an IC50 = 250 nM. AS604850 is selective for the γ-isoform (IC50: PI 3-Kα = 4.5 μM, PI 3-Kβ, PI 3-Kδ > 20 μM) and shows no notable activity against a wide array of protein kinases at 1 μM.
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