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Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Estrogen Receptor > Mifepristone
Mifepristone

CAS:84371-65-3

Appearance:Light yellow to yellow solid

Storage:Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months

Purity:HPLC≥98%

   Manual Download
Mifepristone
Cat.No：
IM0320
Brand：
Solarbio
SKU Tongzhou Beijing Haidian Beijing Wuhan Guangzhou
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Product Information Related Products Related Paper COA Technical Q&A


Examples of using this product（for reference only）

In Vitro:

Cell（HTR-8/SVneo cells，0 ~ 100 ng/mL Mifepristone, 6h）：

Mifepristone (Solarbio) was added in gradient concentrations (0, 25, 50 and 100 ng/ml) to HTR-8/SVneo cells which were pre-exposed to progesterone, and DAF levels were detected 6 h later.

Reference：

Zhang Y, Jin S. Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone. Clin Exp Immunol. 2019 Sep;197(3):376-386. doi: 10.1111/cei.13313. Epub 2019 Jun 20. PMID: 31091357; PMCID: PMC6693963.

In Vivo:

Mice（APS model mouse, 2 mg/kg Mifepristone, from days 5·5 to 15·5.）:

To further confirm the protective effect of progesterone on APS model mouse, we carried out in-vivo progesterone antagonistic experiments. Progesterone (8 mg/kg) was given daily to mice from days 0·5 to 15·5 of pregnancy. Mifepristone (2 mg/kg) was added daily from days 5·5 to 15·5. Mice were euthanized on day 15·5 day of pregnancy. Fetal resorption rates, DAF, C3, interleukin (IL)-1β, IL-8 and tumour necrosis factor (TNF)-α levels were tested to detect the effects of mifepristone on model mice.

Reference：

Zhang Y, Jin S. Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone. Clin Exp Immunol. 2019 Sep;197(3):376-386. doi: 10.1111/cei.13313. Epub 2019 Jun 20. PMID: 31091357; PMCID: PMC6693963.

Remark：
These protocols are for reference only. Solarbio does not independently validate these methods.

Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Experimental Images
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Zhang Y, Jin S. Clin Exp Immunol. 2019 Sep;197(3):376-386. doi: 10.1111/cei.13313.
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