| CAS |
7424-00-2 |
| Chinese Name |
DL-4-氯苯丙氨酸 |
| English Name |
4-Chloro-DL-phenylalanine |
| Synonyms |
DL-4-Chlorophenylalanine;CP-10188;PCPA;Fenchlonine;芬克洛宁 |
| Molecular Formula |
C9H10ClNO2 |
| Molecular Weight |
199.63 |
| Solubility |
Soluble in DMSO ≥5mg/mL(Need ultrasonic or Water bath) |
| Purity |
≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 231-051-9 |
| MDL |
MFCD00002601 |
| SMILES |
NC(CC1=CC=C(Cl)C=C1)C(O)=O |
| InChIKey |
NIGWMJHCCYYCSF-UHFFFAOYSA-N |
| InChI |
InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13) |
| PubChem CID |
4652 |
| Target Point |
Tryptophan Hydroxylase |
| Passage |
Metabolic&Enzyme |
| Background |
Fenclonine is a potent irreversible inhibitor of tryptophan hydroxylase (Trp). |
| Biological Activity |
Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor， which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research[1-3]. |
| In Vivo |
Fenclonine(intraperitoneal injection; 100 mg/kg; once daily; 3 d)treatment can inhibit Morphine-induced anti-nociceptive activity[2].Fenclonine(intraperitoneal injection; 300 mg/kg; once daily; 3 d)pretreatment completely abolishes the effects of a 50 mg/kg dose of Paracetamol[3]. |
| Animal Experiment |
Animal Model: Wistar albino rats of either sex and weighing between 80 and 100 g;Dosage: 100 mg/kg;Administration: Intraperitoneal injection; 100 mg/kg; once daily; 3 days[2] |
| Data Literature Source |
[1]. M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):24S-27S.
[2]. A K Sanyal，et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):247-55.
[3]. Shyamshree S S Manna，et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26(3):268-81. |
| Unit |
Bottle |
| Specification |
50mg 10mM*1mL in DMSO 100mg 500mg |
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