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My CartCAS：1626387-80-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 1626387-80-1 |
| Name | AZD3759 |
| Molecular Formula | C22H23ClFN5O3 |
| Molecular Weight | 459.9 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD29058564 |
| SMILES | ClC1=CC=CC(NC2=NC=NC3=CC(OC)=C(OC(N4[C@H](C)CN(C)CC4)=O)C=C23)=C1F |
| InChIKey | MXDSJQHFFDGFDK-CYBMUJFWSA-N |
| InChI | InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1 |
| PubChem CID | 78209992 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | AZD3759 is a potent EGFR inhibitor. |
| Biological Activity | Zorifertinib (AZD3759)是一种有效的，具有口服活性的，CNS-渗透性EGFR抑制剂，对EGFR (WT)，EGFR (L858R)，和 EGFR (exon 19Del)的IC50分别为0.3 nM，0.2 nM，和 0.2 nM。[1] |
| In Vitro | 在H3255(L858R)细胞中，AZD3759抑制EGFR磷酸化，IC50为7.2 nM。AZD3759对pEGFR通路和EGFR突变基因衍生的细胞PC-9和H3255的增殖表现出抑制作用，IC50分别为7.7 nM和7 nM，对H838细胞的增殖没有活性。[1] |
| In Vivo | AZD3759在狗体内表现出良好的口服活性，并且能够广泛渗透到猴子大脑中。在脑转移性PC-9(Exon19Del)模型中，AZD3759(15 mg/kg)引起显著的剂量依赖性抗肿瘤作用。[1] |
| Data Literature Source | [1] Zeng Q，et al. J Med Chem. 2015，58(20)，8200-8215. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
AZD3759 是一种有效的 EGFR 抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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