L-NAME Hydrochloride_NOS_Immunology & Inflammation_Inhibitors & Antagonists & Agonists_Small Molecule Compounds_Solarbio-Global Leader in Antibody and Elisa Kit

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CAS	51298-62-5
English Name	L-NAME Hydrochloride
Chinese Name	N'-硝基-L-精氨酸甲酯盐酸盐
Synonym	NG-Nitroarginine methyl ester hydrochloride;N(G)-Nitro-L-arginine methyl ester
Unit	Bottle
Purity	HPLC≥98%
Molecular Formula	C₇H₁₅N₅O₄·HCl
Molecular Weight	269.69
Appearance	White to off-white solid
Storage	Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months
Solubility	Soluble in water≥10mg/ml
MDL	MFCD00039052
EC	EINECS 257-116-1
InChIKey	QBNXAGZYLSRPJK-JEDNCBNOSA-N
InChI	InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
PubChem CID	135193
SMILES	N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(OC)=O.[H]Cl
Description	L-NAME hydrochloride is an inhibitor of NOS.
Target Point	NO Synthase
Passage	Immunology & Inflammation
Data Literature Source	[1]. Pfeiffer S, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement forbioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118(6):1433-40. [2]. Kopincová J, et al. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64(3):511-20. [3]. Lo HC, et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11(3):e0151973. [4]. Luo H, et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8. [5]. Ocsan RJ, et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64(6):727-36.
Specification	200mg 10mM*1mL in Water 500mg 1g