CAS |
210344-95-9 |
English Name |
Z-WEHD-FMK |
Synonym |
Z-DEVD-FMK;Caspase-3Inhibitor |
Unit |
Bottle |
Purity |
HPLC≥98% |
Molecular Formula |
C30H41FN4O12 |
Molecular Weight |
668.66 |
Appearance |
White to off-white solid |
Storage |
Powder : -20℃, 2 years;In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO |
MDL |
MFCD00205201 |
InChIKey |
GBJVAVGBSGRRKN-JYEBCORGSA-N |
InChI |
InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1 |
PubChem CID |
16760394 |
SMILES |
O=C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)[C@H](CCC(OC)=O)NC([C@H](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O |
Description |
Z-DEVD-FMK is a specific irreversible caspase-3 inhibitor. |
Target Point |
Caspase |
Passage |
Apoptosis |
IC50 |
Caspase-3:18 μM (IC50) [1-4] |
Data Literature Source |
[1]. Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med. 2006 Nov 15; 41 (10) :1578-89.
[2]. Knoblach SM, et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct; 24 (10) :1119-32.
[3]. Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17 (19) , 7415-7424.
[4]. Huang MY, et al. Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis. Apoptosis. 2016 Feb; 21 (2) :130-42. |
Specification |
1mg 5mg 10mM*1mL in DMSO |