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My CartCAS：59277-89-3
Molecular Formula：C8H11N5O3
Molecular Weight：225.2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 59277-89-3 |
| Name | Acyclovir |
| Molecular Formula | C8H11N5O3 |
| Molecular Weight | 225.2 |
| Solubility | Soluble in DMSO ≥2mg/mL(Need ultrasonic) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 261-685-1 |
| MDL | MFCD00057880 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2COCCO |
| InChIKey | MKUXAQIIEYXACX-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) |
| PubChem CID | 135398513 |
| Target Point | HSV |
| Passage | Anti-infection |
| Background | It is a class of thymidine kinase that can inhibit the herpes virus. |
| Biological Activity | Acyclovir prevents bacterial infections during induction therapy for acute leukaemia. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1-4]. |
| Data Literature Source | [1]. Li Z，et al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10(5):251-7. [2]. Suzuki M，et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. [3]. Benedetti S，et al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells，and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85. [4]. Hayashi K，et al. The role of a HSV thymidine kinase stimulating substance，scopadulciol，in improving the efficacy of cancer gene therapy. J Gene Med. 2006 Aug;8(8):1056-67. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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BMS-265246,a Cyclin-Dependent Kinase Inhibitor,Inhibits the Infection of Herpes Simplex Virus Type 1
Click to check >>Author：Lefang Jiang, Yang Yu, Zhuogang Li, Yarou Gao, Haonan Zhang, Mingxin Zhang, Weihua Cao, Qun Peng, Xulin Chen
IF：4.7000
Publish_to：Viruses-Basel
PMID：37631985
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