CAS |
102518-79-6 |
Chinese Name |
石杉碱甲 |
English Name |
(-)-Huperzine A |
Synonyms |
石杉碱甲;哈伯因 |
Molecular Formula |
C15H18N2O |
Molecular Weight |
242.32 |
Solubility |
Soluble in DMSO |
Purity |
HPLC≥98% |
Appearance |
White to off-white Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC |
EINECS 600-320-6 |
MDL |
MFCD01714949 |
SMILES |
O=C1NC2=C([C@@](/C3=C\C)(N)CC(C)=C[C@@]3([H])C2)C=C1 |
InChIKey |
ZRJBHWIHUMBLCN-ZUZCIYMTSA-N |
InChI |
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1 |
PubChem CID |
449069 |
Target Point |
AChE |
Passage |
Neuronal Signaling |
Background |
HS-1371 is a potent RIP3 kinase inhibitor. |
Biological Activity |
(-)-Huperzine A是从中国草药Huperzia serrata分离出的一种新型的生物碱。(-)-Huperzine A (HupA)是一种有效的,高度特异性的,可逆acetylcholinesterase (AChE)(乙酰胆碱酯酶)抑制剂,Ki为7 nM,作用于G4 AChE比作用于G1 AChE选择性高200倍。(-)-Huperzine A 也是 N-甲基-D-天冬氨酸 (NMDA) 受体的非竞争性拮抗剂。(-)-Huperzine A 被用于神经退行性疾病的研究,包括阿尔茨海默病。[1-4] |
IC50 |
82nM(AChE) [4] |
In Vitro |
(-)-Huperzine A优先抑制四聚体AChE(G4形式)。在抑制AChE活性方面,(-)-Huperzine A比Tacrine,Physostigmine,Galanthamine,和Rivastigmine更有效,但是在抑制BuChE方面,(-)-Huperzine A效果却是最差的。(-)-Huperzine A 保护细胞免受过氧化氢,β-淀粉样蛋白,谷氨酸盐,缺血和Staurosporine 诱导的细胞毒性和细胞凋亡。这些保护作用与其减轻氧化应激,调节凋亡蛋白Bcl-2,Bax,P53,和caspase-3的表达,保护线粒体,上调神经生长因子及其受体,及干扰淀粉样前体蛋白代谢有关。[3] |
In Vivo |
(-)-Huperzine A 处理动物模型和AD患者,可以改善学习和记忆障碍。(-)-Huperzine A有益功能包括:β-淀粉样蛋白肽加工的修饰,减少氧化应激,保护神经元防止细胞凋亡,调控神经生长因子(NGF)及NGF信号的表达和分泌。[2]大鼠杀害30分钟后,使用不同剂量水平的(-)-Huperzine A处理,对照组使用生理盐水,(-)-Huperzine A显著抑制皮质,海马区,纹状体,内侧隔核,延髓,小脑和丘脑中的乙酰胆碱酯酶活性。[3] |
Cell Experiment |
(-)-Huperzine A(0.1-0.2 mg/kg; i.p.; daily; for 12 days)can alleviate the cognitive dysfunction and neuronal degeneration induced by i.c.v. infusion of beta-amyloid protein-(1-40)in rats[5]. |
Data Literature Source |
[1] Zhao Q,et al. Eur J Pharmacol,2002,455(2-3),101-107. [2] Zhang HY,et al. Trends Pharmacol Sci,2006,27(12),619-625. [3] Wang R,et al. Acta Pharmacol Sin,2006,27(1),1-26. [4]. MA Xiao-Chao,XIN Jian,WANG Hai-Xue,et al. Acute effects of huperzine A and tacrine on rat liver. Acta Pharmacol ogica Sinica,2003,24(3):247-250. [5]. R Wang,et al. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. Eur J Pharmacol. 2001 Jun 15;421(3):149-56. |
Unit |
Bottle |
Specification |
5mg 10mM*1mL in DMSO 10mg |