| CAS |
315-22-0 |
| Chinese Name |
野百合碱 |
| English Name |
Crotaline |
| Synonyms |
Monocrotaline |
| Molecular Formula |
C16H23NO6 |
| Molecular Weight |
325.36 |
| Solubility |
Soluble in DMSO ≥10mg/mL |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 628-506-2 |
| MDL |
MFCD00084656 |
| SMILES |
O=C(O[C@]1([H])CCN2[C@]1([H])C(CO3)=CC2)[C@H](C)[C@@](C)(O)[C@@](C)(O)C3=O |
| InChIKey |
QVCMHGGNRFRMAD-XFGHUUIASA-N |
| InChI |
InChI=1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1 |
| PubChem CID |
9415 |
| Target Point |
Others |
| Passage |
Others |
| Background |
It is a pyrrolizidine alkaloid, which has inhibitory effect on various tumors, and is considered to be an alkylating agent, which exerts anticancer activity through the alkylation of DNA. |
| In Vitro |
野百合碱(MCT)是一种11元大环吡咯里西啶生物碱(PA)，来源于猪屎豆(Crotalaria spectabilis)植物的种子[1]。野甘露碱是一种天然配体，具有剂量依赖性细胞毒性，具有强大的抗肿瘤活性。野百合碱的体外细胞毒性证实为IC50为24.966μg/ mL，2 X IC50对HepG2细胞的遗传毒性[2]。 |
| In Vivo |
MCT引起大鼠肺血管综合征，其特征为增殖性肺血管炎，肺动脉高压(PH)和肺心病[3]。在肺动脉高压(PAH)的临床前模型中，野百合碱动物模型提供了模拟人PAH几个关键方面的优势，包括血管重塑，平滑肌细胞增殖，内皮功能障碍，炎性细胞因子上调和右心室衰竭，需要单次注射药物[4]。通过注射野百合碱观察到与PH发展相关的多种途径的变化，包括活化的糖酵解，增加的增殖标记，肉毒碱稳态的破坏，炎症和纤维化生物标志物的增加以及谷胱甘肽生物合成的减少[5]。 |
| Animal Experiment |
大鼠：在该研究中使用总共20只雄性Sprague Dawley大鼠(SD; 220-270g)(每组n = 10)。对照组接受野百合碱(MCT)的载体。肺动脉高压前期(PH)组单次注射MCT(60 mg / kg ip)诱导并在14天后处死[5]。 |
| Data Literature Source |
[1]. Gomez-Arroyo JG， et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15; 302 (4) :L363-9.
[2]. Kusuma SS， et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma. Anticancer Agents Med Chem. 2014; 14 (9) :1237-48.
[3]. Wilson DW， et， al. Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit Rev Toxicol. 1992; 22 (5-6) :307-25.
[4]. Nogueira-Ferreira R， et al. Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach. Pulm Pharmacol Ther. 2015 Dec; 35:8-16.
[5]. Rafikova O，et al. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed RatLung. PLoS One. 2016 Mar 3; 11 (3) :e0150480. |
| Unit |
Bottle |
| Specification |
20mg 10mM*1mL in DMSO 100mg |
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