| CAS |
19309-14-9 |
| Chinese Name |
小豆蔻明 |
| English Name |
Cardamonin |
| Synonyms |
小豆蔻明;alpinetinchalcone; |
| Molecular Formula |
C16H14O4 |
| Molecular Weight |
270.28 |
| Solubility |
Soluble in DMSO ≥10mg/mL |
| Purity |
HPLC≥98% |
| Appearance |
Light yellow to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD00238554 |
| SMILES |
O=C(C1=C(OC)C=C(O)C=C1O)/C=C/C2=CC=CC=C2.[E] |
| InChIKey |
NYSZJNUIVUBQMM-BQYQJAHWSA-N |
| InChI |
InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ |
| PubChem CID |
641785 |
| Target Point |
TRP Channel;NF-κB |
| Passage |
Membrane Transporter&Ion Channel;Neuronal Signaling;NF-κB |
| Background |
Cardamonin is a hTRPA1 cationic channel antagonist and a NF-kB inhibitor. |
| Biological Activity |
(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.[1-2] |
| IC50 |
454nM(hTRPA1 cation channel)[1] |
| In Vitro |
Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway，which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase(MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway[2]. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel[1]. |
| In Vivo |
Cardamonin inhibits tumor growth in vivo without serious side effects[2]. |
| Cell Experiment |
Cell viability assay: NPC cells are treated with 10 μM cardamonin or 0.1% DMSO，absorbance is measured after 24，48 and 72 h of treatment.[2] |
| Animal Experiment |
Animal Models: Xenograft model(BALB/c nude mice); Dosages: 5 mg/kg; Administration: i.p.[2] |
| Data Literature Source |
[1] Wang S，et al. Molecules. 2016 Aug 29;21(9):pii: E1145.
[2] Yuting Li，et al. Cell Death Dis. 2017，8(8): e3024. |
| Unit |
Bottle |
| Specification |
10mg 10mM*1mL in DMSO 20mg |
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