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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-MAPK14 Monoclonal Antibody
Chinese Name	丝裂原活化蛋白激酶14抗体
Host	Mouse
Clone Type	Monoclonal Antibody
Subtype	IgG1
Clone Number	5A1-C5-F11
Dilution Ratio	WB 1:500-1000.
Target	MAPK14
Synonyms	CSBP;CSBP1;CSBP2;CSPB1;EXIP;Mxi2;p38;p38ALPHA;PRKM14;PRKM15;RK;SAPK2A
Background	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Swiss Prot	Q16539
Gene ID	1432
Subcellular Location	Cytoplasm Nucleus
Immunogen	Recombinant protein of human MAPK14
Calculated MW	41kDa
Purification Method	Affinity purification
Storage Buffer	PBS with 0.02% sodium azide，0.5% BSA，50% glycerol，pH7.3.
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Mouse Rat Monkey Human
Application	WB