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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-STAT3 Monoclonal Antibody
Chinese Name	信号传导与转录激活因子3抗体
Host	Mouse
Clone Type	Monoclonal Antibody
Subtype	IgG1
Clone Number	4C8-1C9-H8
Dilution Ratio	WB 1:500-1000.
Target	STAT3
Synonyms	ADMIO;ADMIO1;APRF;HIES;ADMIO;APRF;HIES
Background	The protein encoded by this gene is a member of the STAT protein family.In response to cytokines and growth factors,STAT family members are phosphorylated by the receptor associated kinases,and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs,EGF,IL5,IL6,HGF,LIF and BMP2.This protein mediates the expression of a variety of genes in response to cell stimuli,and thus plays a key role in many cellular processes such as cell growth and apoptosis.The small GTPase Rac1 has been shown to bind and regulate the activity of this protein.PIAS3 protein is a specific inhibitor of this protein.Three alternatively spliced transcript variants encoding distinct isoforms have been described.[provided by RefSeq,Jul 2008]
Swiss Prot	P40763
Gene ID	6774
Subcellular Location	Cytoplasm Nucleus
Immunogen	Recombinant protein of human STAT3
Calculated MW	83/88kDa
Purification Method	Affinity purification
Storage Buffer	PBS with 0.02% sodium azide，0.5% BSA，50% glycerol，pH7.3.
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Rat Mouse Monkey Hamster Human
Application	WB