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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-TLR3 Monoclonal Antibody
Chinese Name	Toll样受体3抗体
Host	Mouse
Clone Type	Monoclonal Antibody
Subtype	IgG2b
Clone Number	2F10-B8-G9
Dilution Ratio	WB 1:500-1000.
Target	TLR3
Synonyms	Toll-like receptor 3, TLR3, CD283, CD283 antigen, TLR 3, Toll Like Receptor 3, TLR3_HUMAN
Background	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
Swiss Prot	O15455
Gene ID	7098
Subcellular Location	Early endosome Endoplasmic reticulum membrane Endosome membrane Single-pass type I membrane protein
Immunogen	Recombinant protein of human TLR3
Calculated MW	73/104kDa
Purification Method	Affinity purification
Storage Buffer	PBS with 0.02% sodium azide，0.5% BSA，50% glycerol，pH7.3.
Storage	Store at -20℃. Avoid freeze / thaw cycles.
Unit	Piece
Specification	50ul 100ul
Reactivity	Transfected
Application	WB