English Name |
Anti-NUP98 Monoclonal Antibody |
Host |
Mouse |
Clone Type |
Monoclonal Antibody |
Subtype |
IgG1 |
Clone Number |
3B8-D7-H10 |
Dilution Ratio |
WB 1:500-1000. IP 1:20. |
Target |
NUP98 |
Synonyms |
96 kDa nucleoporin, 98 kDa nucleoporin, ADAR2, ADIR2, GLFG-repeat containing nucleoporin, Nuclear pore complex protein Nup96, Nuclear pore complex protein Nup98 Nup96, Nucleoporin 98kD, nucleoporin 98kDa, Nucleoporin Nup96, Nucleoporin Nup98, NUP196, NUP96, Nup98, Nup98-Nup96, NUP98_HUMAN |
Background |
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
Swiss Prot |
P52948 |
Gene ID |
4928 |
Subcellular Location |
Nucleoplasmic side Nucleus Nucleus membrane Peripheral membrane protein nuclear pore complex |
Immunogen |
Recombinant protein of human NUP98 |
Calculated MW |
198/187/98kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,0.5% BSA,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Unit |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human |