English Name |
Anti-ATP2A2 Polyclonal Antibody |
Chinese Name |
钙离子转运ATP酶A2抗体 |
Target |
ATP2A2 |
Synonym |
ATP dependent calcium pumpsc, ATP2A2, ATP2B, ATPase Ca++ transporting cardiac muscle slow twitch 2, Ca++ transporting cardiac muscle slow twitch 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type slow twitch skeletal muscle isoform, DAR, Darier disease, DD, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, Sarcoplasmic or endoplasmic reticulum calcium ATP, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA 2, SERCA2, SR Ca(2+)-ATPase 2, AT2A2_HUMAN |
Backgroud |
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Swiss Prot |
P16615 |
Gene ID |
488 |
Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein Sarcoplasmic reticulum membrane |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
115kDa |
Dilution Ratio |
WB 1:500-2000.IHC 1:50-100 |
Immunogen |
Recombinant protein of human ATP2A2 |
Public Immunogen Range |
111-253aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Mouse Rat |
Application |
WB IHC |
Specification |
50ul 100ul |