Anti-ATF6 Polyclonal Antibody_Primary Antibodies_Antibodies_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
K001590P-100ul	Inquiry	Inquiry	Inquiry	Inquiry
K001590P-50ul	Inquiry	Inquiry	Inquiry	Inquiry

English Name	Anti-ATF6 Polyclonal Antibody
Chinese Name	活化转录因子6抗体
Target	ATF6
Synonym	Activating transcription factor 6 alpha, Activating transcription factor 6, ATF 6, ATF6 alpha, ATF6, ATF6-alpha, ATF6A, ATF6A_HUMAN, cAMP dependent transcription factor ATF 6 alpha, cAMP-dependent transcription factor ATF-6 alpha, Cyclic AMP dependent transcription factor ATF 6 alpha, DKFZp686P2194, ESTM49, FLJ21663, Processed cyclic AMP dependent transcription factor ATF 6 alpha, Processed cyclic AMP-dependent transcription factor ATF-6 alpha
Backgroud	This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Swiss Prot	P18850
Gene ID	22926
Subcellular Localization	Endoplasmic reticulum membrane Nucleus Single-pass type II membrane protein
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Protein MW	75kDa
Dilution Ratio	WB 1:500-1000. IF 1:50-200. IHC 1:50-200.
Immunogen	Recombinant protein of human ATF6
Public Immunogen Range	1-190aa
Purification Method	Affinity purification
Storage Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage	Store at -20℃, avoid freeze/thaw cycles.
Unit	Piece
Cross-Reactivity	Human Mouse Rat
Application	WB IHC IF
Specification	50ul 100ul