Anti-LMNA Polyclonal Antibody_Nuclear Membrane_Loading Control Antibodies_Antibodies

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
K001627P-100ul	Inquiry	Inquiry	Inquiry	Inquiry
K001627P-50ul	Inquiry	Inquiry	Inquiry	Inquiry

English Name	Anti-LMNA Polyclonal Antibody
Chinese Name	层粘连蛋白A/C抗体
Target	LMNA
Synonym	CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LDP1;LFP;LGMD1B;LMN1;LMNC;LMNL1;MADA;PRO1;Lamin A/C
Backgroud	The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Swiss Prot	P02545
Gene ID	4000
Subcellular Localization	Nucleus Nucleus envelope Nucleus lamina Nucleus speckle nucleoplasm
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Protein MW	74/65/71/64/63/69kDa
Dilution Ratio	WB 1:500-1000. IHC 1:50-200. IF 1:50-200. ChIP 1:20-100.
Immunogen	Recombinant protein of human LMNA
Public Immunogen Range	403-572aa
Purification Method	Affinity purification
Storage Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage	Store at -20℃, avoid freeze/thaw cycles.
Unit	Piece
Cross-Reactivity	Human Rat Mouse
Application	WB IHC IF ChIP
Specification	50ul 100ul