English Name |
Anti-FZD6 Polyclonal Antibody |
Chinese Name |
卷曲蛋白6抗体 |
Target |
FZD6 |
Synonym |
Frizzled 6 seven transmembrane spanning receptor, Frizzled drosophila homolog of 6, Frizzled family receptor 6, Frizzled homolog 6 (Drosophila), Frizzled homolog 6, Frizzled-6, Frizzled6, Fz 6, Fz-6, Fz6, FZD 6, Fzd6, FZD6_HUMAN, Hfz 6, hFz6, NDNC10 |
Backgroud |
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. |
Swiss Prot |
O60353 |
Gene ID |
8323 |
Subcellular Localization |
Apical cell membrane Cell membrane Cell surface Cytoplasmic vesicle membrane Membrane Multi-pass membrane protein |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
79kDa |
Dilution Ratio |
WB 1:1000-2000. |
Immunogen |
Recombinant protein of human FZD6 |
Public Immunogen Range |
19-201aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Mouse Rat |
Application |
WB |
Specification |
50ul 100ul |