English Name |
Anti-TTR Polyclonal Antibody |
Chinese Name |
甲状腺素转运蛋白抗体 |
Target |
TTR |
Synonym |
Transthyretin, Amyloid polyneuropathy, Amyloidosis I, ATTR, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, PALB, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TBPA, Transthyretin, TTR, TTR protein, prealbumin, TTHY_HUMAN |
Backgroud |
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. |
Swiss Prot |
P02766 |
Gene ID |
7276 |
Subcellular Localization |
Cytoplasm Secreted |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
16kDa |
Dilution Ratio |
WB 1:500-1000. IHC 1:50-100. IF 1:50-100 |
Immunogen |
Recombinant protein of human TTR |
Public Immunogen Range |
21-147aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse Rat |
Application |
WB IHC IF |
Specification |
50ul 100ul |